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KMID : 0366220090440040227
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Korean Journal of Hematology
2009 Volume.44 No. 4 p.227 ~ p.236
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Influence of Serum Ferritin on Transplant-related Outcomes and Complications in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
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Lee Yun-Jeong
Cho Hyung-Rae
Bae Keun-Wook
Park Mee-Rim
Koh Kyung-Nam
Song Joon-Sup
Im Ho-Joon
Seo Jong-Jin
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Abstract
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Background: Iron overload, primarily related to RBC transfusions, is a relatively common complication in hematopoietic stem cell transplant (HSCT) recipients. There are emerging data from retrospective studies that iron overload can significantly increase the risk of nonrelapse mortality after allogeneic HSCT.
Methods: One hundred and five children who received allogeneic HSCT between Jan 2004 and Feb 2009 at Asan Medical Center were analyzed. For indirect estimation of body iron stores, we measured serum ferritin serially in HSCT recipients at pre-transplant, 3 months and 1 year post-transplant. We also analyzed prevalence of hyperferritinemia, correlation of iron overload and transplant-related outcomes and complications.
Results: The prevalence of hyperferritinemia (≥1,000 ?g/L) at pre-HSCT, 3 months and 1 year post-HSCT were 66.7% (70/105), 78% (71/91) and 40.9% (27/66), respectively. Children with hyperferritinemia (≥1,000 ?g/L) at 3 months post-HSCT had worse 2-year OS (79% vs 95%; P=0.023) than those in the low ferritin group (＜1,000 ?g/L). Very high levels (VHL) of ferritin (≥3,000 ?g/L) at 3 months post-HSCT were associated with increased incidence of treatment related mortality (23% vs 2%, P=0.001) and acute graft-versus-host disease (54% vs 26%, P=0.007) in univariate analysis. VHL of ferritin remained significant in multivariate analysis.
Conclusion: Hyperferritinemia at 3 months post-HSCT had adverse impact for transplantation outcome in patients undergoing allogeneic stem cell transplantation. These results suggest that the screening and adequate treatment of iron overload in HSCT recipients might be helpful to improve the HSCT outcomes. (Korean J Hematol 2009;44:227-236.)
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KEYWORD
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Iron overload, Ferritin, Hematopoietic stem cell transplantation, Pediatrics
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